Pax3 et Pax7 : gardiens du développement craniofacial
نویسندگان
چکیده
منابع مشابه
03-P130 Pax3 and Pax7 play key functions in craniofacial development
The study of wound closure is important for the advancement of medicinal applications in surgical scar healing, as well as initiation of tissue regeneration. Research on wound closure has primarily focused on vertebrate models, although the process is found throughout all animal groups. Non-vertebrate models provide efficient cost-effective tools for examining the general properties necessary f...
متن کاملComparative expression analysis of Pax3 and Pax7 during mouse myogenesis.
Pax3 and Pax7 are closely related transcription factors involved in the commitment of myogenic precursors in the developing trunk. However, it is not yet clear whether these genes are required for myogenic cell specification in the head and for post-somitic myogensis per se. In part, this uncertainty is due to the scarce information about their normal time course and pattern of expression. Here...
متن کاملDistinct roles for Pax7 and Pax3 in adult regenerative myogenesis
We assessed viable Pax7(-/-) mice in 129Sv/J background and observed reduced growth and marked muscle wasting together with a complete absence of functional satellite cells. Acute injury resulted in an extreme deficit in muscle regeneration. However, a small number of regenerated myofibers were detected, suggesting the presence of residual myogenic cells in Pax7-deficient muscle. Rare Pax3(+)/M...
متن کاملPax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin.
To investigate the role of the translocation-associated gene Pax3:Fkhr in alveolar rhabdomyosarcomas, we generated a Cre-mediated conditional knock-in of Pax3:Fkhr into the mouse Pax3 locus. Exploring embryonic tumor cell origins, we replaced a Pax3 allele with Pax3:Fkhr throughout its expression domain, causing dominant-negative effects on Pax3 and paradoxical activation of the Pax3 target gen...
متن کاملPax3 functions in cell survival and in pax7 regulation.
In developing vertebrate embryos, Pax3 is expressed in the neural tube and in the paraxial mesoderm that gives rise to skeletal muscles. Pax3 mutants develop muscular and neural tube defects; furthermore, Pax3 is essential for the proper activation of the myogenic determination factor gene, MyoD, during early muscle development and PAX3 chromosomal translocations result in muscle tumors, provid...
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ژورنال
عنوان ژورنال: médecine/sciences
سال: 2015
ISSN: 0767-0974,1958-5381
DOI: 10.1051/medsci/20153108007